Enzymatic conversion of 3-hydroxyanthranilic acid to nicotinic acid.
نویسنده
چکیده
The apparent conversion of tryptophan to nicotinic acid has been observed for several animal species (cf. (1)). Other studies demonstrated that at least some of the nicotinic acid (or amide) was synthesized within the tissues of the animal (2, 3). It was of interest to extend these studies and the ability of liver slices to synthesize nicotinic acid from its biologically active intermediate, 3-hydroxyanthranilic acid (4, 5), was investigated. The results of these studies are reported in this paper.
منابع مشابه
3-hydroxyanthranilic Acid Metabolism
The participation of 3-hydroxyanthranilic acid as an intermediate in the biosynthesis of nicotinic acid from tryptophan was first demonstrated in certain mutant strains of Neurospora in 1948 by Bonner (1) and by Mitchell and Nyc (2). In addition, Mitchell et al. (3) found that 3-hydroxyanthranilic acid can replace nicotinic acid in the nutrition of the rat. In 1946 Singal et al. (4) noted a sub...
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In 1945, Krehl et al. (1) observed that tryptophan and nicotinic acid were mutually interchangeable, within limits, in supporting the growth of rats. Since that time considerable evidence has accumulated which demonstrates the biosynthesis of niacin from tryptophan in the rat and other animals. Studies with Neurospora and mammals have demonstrated that the pathway from tryptophan goes through k...
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Yeasts utilize tryptophan for the synthesis of nicotinic acid under aerobic, but not under anaerobic, conditions. Under aerobic conditions of growth, radioactivity from tryptophanJ4C uniformly labeled in the benzene ring and 14C!-carboxyl-labeled 3-hydroxyanthranilic acid is incorporated into nicotinic acid. Under anaerobic conditions, little radioactivity from these compounds is incorporated i...
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Yeasts utilize tryptophan for the synthesis of nicotinic acid under aerobic, but not under anaerobic, conditions. Under aerobic conditions of growth, radioactivity from tryptophanJ4C uniformly labeled in the benzene ring and 14C!-carboxyl-labeled 3-hydroxyanthranilic acid is incorporated into nicotinic acid. Under anaerobic conditions, little radioactivity from these compounds is incorporated i...
متن کاملChanges in the Enzymatic Composition of Liver*
Rats made diabetic with alloxan have been shown to excrete less Nmethylnicotinamide than normal rats when given test doses of tryptophan (2). The present investigation was designed to determine the nature of the enzymatic alteration responsible for the difference between the two groups of animals. A deficiency in one or more of the enzymes needed for the conversion of tryptophan to nicotinic ac...
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عنوان ژورنال:
- The Journal of biological chemistry
دوره 178 2 شماره
صفحات -
تاریخ انتشار 1949